CD4+T Cells Acting Independently of Antibody Contribute to Protective Immunity toPlasmodiumchabaudiInfection After Apical Membrane Antigen 1 Immunization
نویسندگان
چکیده
منابع مشابه
Specificity of the protective antibody response to apical membrane antigen 1.
Apical membrane antigen 1 (AMA1) is considered one of the leading candidates for inclusion in a vaccine against blood stages of Plasmodium falciparum. Although the ama1 gene is relatively conserved compared to those for some other potential vaccine components, numerous point mutations have resulted in amino acid substitutions at many sites in the polypeptide. The polymorphisms in AMA1 have been...
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Plasmodium vivax apical membrane antigen-1(PvAMA-1) is a surface protein with polymorphic sites. This study was aimed to analyze the polymorphic amino acid residues at PvAMA-1 in different infected age groups. 92 blood samples were collected from south and southeast of Iran. The DNA coding for the domain I (DI), DII, and partial DIII of this antigen was amplified by Nested-PCR, and sequenced. N...
متن کاملImmunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model.
Apical membrane antigen 1 (AMA-1) is a leading blood-stage malaria vaccine candidate. Consistent with a key role in erythrocytic invasion, AMA-1-specific antibodies have been implicated in AMA-1-induced protective immunity. AMA-1 is also expressed in sporozoites and in mature liver schizonts where it may be a target of protective cell-mediated immunity. Here, we demonstrate for the first time t...
متن کاملOvercoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.
Apical membrane antigen 1 (AMA1) is a leading vaccine candidate, but the allelic polymorphism is a stumbling block for vaccine development. We previously showed that a global set of AMA1 haplotypes could be grouped into six genetic populations. Using this information, six recombinant AMA1 proteins representing each population were produced. Rabbits were immunized with either a single recombinan...
متن کاملImmunity in Leprosy, in Relation to Antibody Titers of Epstein-Barr Virus Capsid Antigen
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2000
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.165.1.389